Coxsackievirus B5 induced apoptosis of HeLa cells : effects on p53 and SUMO.
Nenhuma Miniatura disponível
Data
2010
Autores
Gomes, Rogério
Cota, Renata Guerra de Sá
Arruda, Eurico
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Coxsackievirus B5 (CVB5), a human enterovirus of the family Picornaviridae, is a frequent cause of acute and chronic human diseases. The pathogenesis of enteroviral infections is not completely understood, and the fate of the CVB5-infected cell has a pivotal role in this process. We have investigated the CVB5-induced apoptosis of HeLa cells and found that it happens by the intrinsic pathway by a mechanism dependent on the
ubiquitin–proteasome system, associated with nuclear aggregation of p53. Striking redistribution of both SUMO and UBC9 was noted at 4 h post-infection, simultaneously with a reduction in the levels of the ubiquitin-ligase HDM2. Taken together, these results suggest that CVB5 infection of HeLa cells elicit the intrinsic pathway of apoptosis by MDM2 degradation and p53 activation, destabilizing protein sumoylation, by a mechanism that is dependent on a functional ubiquitin–proteasome system.
Descrição
Palavras-chave
Coxsackievirus B5, Apoptosis
Citação
GOMES, R.; SÁ, R. G.; ARRUDA, E. Coxsackievirus B5 induced apoptosis of HeLa cells: effects on p53 and SUMO. Journal of Virology, v. 396, p. 256-263, 2010. Disponível em: <http://www.sciencedirect.com/science/article/pii/S004268220900614X>. Acesso em: 08 nov. 2014.