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dc.contributor.authorDuarte, Rinaldo-
dc.contributor.authorSilva, A. M.-
dc.contributor.authorVieira, Leda Quercia-
dc.contributor.authorAfonso, Luís Carlos Crocco-
dc.contributor.authorNicoli, Jacques Robert-
dc.date.accessioned2015-03-03T16:39:24Z-
dc.date.available2015-03-03T16:39:24Z-
dc.date.issued2005-
dc.identifier.citationDUARTE, R. et al. Trypanosoma cruzi: influence of predominant bacteria from indigenous digestive microbiota on experimental infection in mice. Experimental Parasitology, Inglaterra, v. 111, p. 87-96, 2005. Disponível em: <http://www.sciencedirect.com/science/article/pii/S001448940500175X>. Acesso em: 08 nov. 2014.pt_BR
dc.identifier.issn0014-4894-
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4522-
dc.description.abstractTo verify the inXuence of some predominant components from indigenous microbiota on systemic immunological responses during experimental Chagas disease, germ-free NIH Swiss mice were mono-associated with Escherichia coli, Enterococcus faecalis, Bacteroides vulgatus or Peptostreptococcus sp. and then infected with the Y strain of Trypanosoma cruzi. All the mono-associations predominantly induced a Th1 type of speciWc immune response to the infection by T. cruzi. A direct correlation was observed between a higher survival rate and increased IFN-_ and TNF-_ production (P<0.05) in E. faecalis-, B. vulgatus-, and Peptostreptococcus- associated mice. Moreover, higher levels of anti-T. cruzi IgG1 and anti-T. cruzi IgG2a were also found in mono-associated animals after infection. On the other hand, with the exception of E. faecalis-associated mice, mono-association induced a lower IL-10 production after infection (P< 0.05) when compared with germ-free animals. Interestingly, spleen cell cultures from non-infected germ-free and mono-associated mice spontaneously produced higher levels (P< 0.05) of IL-10 than cultures from infected monoassociated mice, except again for E. faecalis-associated animals. In conclusion, the presence of the components of the indigenous microbiota skews the immune response towards production of inXammatory cytokines during experimental infection with T. cruzi in gnotobiotic mice. However, the degree of increase in production of cytokines depends on each bacterial component.pt_BR
dc.language.isoen_USpt_BR
dc.subjectMicrobiotapt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectCytokinespt_BR
dc.subjectImmunoglobulinspt_BR
dc.subjectGnotobiotic micept_BR
dc.titleTrypanosoma cruzi : influence of predominant bacteria from indigenous digestive microbiota on experimental infection in mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3530901345233.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.exppara.2005.06.002-
Appears in Collections:DECBI - Artigos publicados em periódicos

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