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Title: IgG isotype profile is correlated with cardiomegaly in Beagle dogs infected with distinct Trypanosoma cruzi strains.
Authors: Guedes, Paulo Marcos da Matta
Veloso, Vanja Maria
Gollob, Kenneth John
Afonso, Luís Carlos Crocco
Caldas, Ivo Santana
Vianna, Priscila
Lana, Marta de
Chiari, Egler
Bahia, Maria Terezinha
Galvão, Lúcia Maria da Cunha
Keywords: Trypanosoma cruzi
Chagas disease
Beagle dogs
Immunoglobulin G isotype
Issue Date: 2008
Citation: GUEDES, P. M. M. et al. IgG isotype profile is correlated with cardiomegaly in Beagle dogs infected with distinct Trypanosoma cruzi strains. Veterinary Immunology and Immunopathology, v. 124, p. 163-168, 2008. Disponível em: <>. Acesso em: 20 ago. 2014.
Abstract: A systematic study following infection by various strains of the protozoan parasite, Trypanosoma cruzi, and the simultaneous monitoring of the humoral immune response together with the elicited cellular response, could add greatly to our understanding of differences between strains of this important human pathogen. In that sense, acute and chronic infections with distinct T. cruzi strains (Y, Berenice-78 and ABC) in Beagle dogs were studied through a longitudinal evaluation of immunoglobulin G (IgG), IgG1 and IgG2 isotypes (by ELISA and flow cytometry (FC)), as well as measurements of peripheral blood mononuclear cell (PBMC) proliferation over a 100-week period, and their correlation with cardiomegaly. Our results show that infected animals presenting cardiomegaly showed lower or absent levels of IgG1 during the chronic phase of the infection, when compared to those that did not show an increase in heart weight. In that manner, our results suggest that IgG1 could be used as a marker for cardiac pathogenicity in Chagas disease.
ISSN: 0014-4894
metadata.dc.rights.license: O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3483170557595.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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