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http://www.repositorio.ufop.br/jspui/handle/123456789/3864
Title: | Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae). |
Authors: | Duarte, Lucienir Pains Vieira Filho, Sidney Augusto Silva, Grácia Divina de Fátima Sousa, José Rego de Pinto, Artur da Silveira |
Keywords: | Austroplenckia populnea Pentacyclic triterpenes Anti-trypanosomal activity Growth inhibition |
Issue Date: | 2002 |
Citation: | DUARTE, L. P. et al. Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae). Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 44, n.2, p. 109-112, 2002. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&nrm=iso&lng=pt&tlng=pt&pid=S0036-46652002000200010>. Acesso em: 20 ago. 2014. |
Abstract: | Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20_-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds. |
URI: | http://www.repositorio.ufop.br/handle/123456789/3864 |
metadata.dc.identifier.doi: | http://dx.doi.org/10.1590/S0036-46652002000200010 |
ISSN: | 0036-4665 |
metadata.dc.rights.license: | A Revista do Instituto de Medicina Tropical de São Paulo permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida por email enviado no dia 06/12/2013. |
Appears in Collections: | DEFAR - Artigos publicados em periódicos |
Files in This Item:
File | Description | Size | Format | |
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ARTIGO_AntiTrypanosomalActivity.pdf | 56,51 kB | Adobe PDF | View/Open |
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