Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/3857
Title: Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease.
Authors: Silva, Rafael Rodrigues
Bajracharya, Deena Shrestha
Leite, Camila Megale Almeida
Leite, Romulo
Bahia, Maria Terezinha
Silva, André Talvani Pedrosa da
Keywords: Chagas cardiomyopathy
Trypanosoma cruzi
Simvastatin
Chemokines
Inflammation
Issue Date: 2012
Citation: SILVA, R. R. et al. Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 107, p. 513-521, 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000400012&lng=en&nrm=iso&tlng=en>. Acesso em: 20 ago. 2014.
Abstract: Trypanosoma cruzi infection induces progressive cardiac inflammation that leads to fibrosis and modifications in the heart architecture and functionality. Statins, such as 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, have been studied due to their pleiotropic roles in modulating the inflammatory response. Our goal was to evaluate the effects of simvastatin on the cardiac inflammatory process using a cardiotropic strain of T. cruzi in a murine model of Chagas cardiomyopathy. C57BL/6 mice were infected with 500 trypomastigotes of the Colombian strain of T. cruzi and treated with an oral dose of simvastatin (20 mg/Kg/day) for one month and inflam-matory and morphometric parameters were subsequently evaluated in the serum and in the heart, respectively. Simvastatin reduced the total cholesterol and inflammatory mediators (interferon-gamma, tumour necrosis factor-alpha, CCL2 and CCL5) in the serum and in the heart tissue at 30 days post-infection. Additionally, a proportional reduction in heart weight and inflammatory infiltration was observed. Simvastatin also reduced epimastigote pro¬liferation in a dose-dependent manner in vitro and was able to reduce blood trypomastigotes and heart amastigote nests during the acute phase of Chagas disease in vivo. Based on these data, we conclude that simvastatin exerts a modulatory effect on the inflammatory mediators that are elicited by the Colombian strain of T. cruzi and amelio¬rates the heart damage that is observed in a murine model of Chagas disease.
URI: http://www.repositorio.ufop.br/handle/123456789/3857
metadata.dc.identifier.doi: http://dx.doi.org/10.1590/S0074-02762012000400012
ISSN: 0074-0276
metadata.dc.rights.license: O periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12 dez. 2013.
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