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Título: | Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni : a field-based study in Brazil. |
Autor(es): | Marinho, Carolina Coimbra Bretas, Thales Voieta, Izabela Queiroz, Leonardo Campos de Ruiz Guevara, Raiza Teixeira, Antônio Lúcio Antunes, Carlos Mauricio de Figueiredo Prata, Aluízio Lambertucci, José Roberto |
Palavras-chave: | Schistosomiasis Ultrasound Liver fibrosis Hepatosplenic schistosomiasis Fibrosis markers |
Data do documento: | 2010 |
Referência: | MARINHO, C. C. et al. Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni : a field-based study in Brazil. Memórias do Instituto Oswaldo Cruz, v. 105, p. 471-478, 2010. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400020&lng=en&nrm=iso&tlng=en>. Acesso em: 01 set. 2014. |
Resumo: | Non-invasive markers of fibrosis have been used to diagnose liver fibrosis in a variety of diseases. Hyaluronic acid (HA) and collagen IV (C-IV) levels were measured in the sera of patients from an endemic area for schistoso¬miasis in Brazil to diagnose and to rank the intensity of liver fibrosis. Seventy-nine adult patients with schistoso¬miasis, in the age range of 21-82 years (49 ± 13.4) were submitted to clinical and ultrasonographic examinations. Ultrasound was employed to diagnose and categorise liver fibrosis according to World Health Organization pat¬terns. Serum HA and C-IV levels were measured using commercial ELISA kits. Ultrasound revealed six patients with intense liver fibrosis, 21 with moderate, 23 with light and 29 without. Serum HA was able to separate individuals with fibrosis from those without (p < 0.001) and light from intense fibrosis (p = 0.029), but C-IV was not (p = 0.692). The HA diagnostic accuracy for fibrosis was 0.89. The 115.4 ng/mL cut-off level diagnosed patients with fibrosis (sensitivity 0.98, specificity 0.64). HA correlated positively with portal hypertension. Periportal fibrosis (subjective evaluation), age and collateral circulation predicted HA increase. In conclusion, we propose that serum HA can be used to identify patients with liver fibrosis in an endemic area for schistosomiasis mansoni in Brazil. |
URI: | http://www.repositorio.ufop.br/handle/123456789/3795 |
DOI: | http://dx.doi.org/10.1590/S0074-02762010000400020 |
ISSN: | 0074-0276 |
Licença: | O periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12 dez. 2013. |
Aparece nas coleções: | DEMSC - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_SerumHyaluronanCollagen.pdf | 421,47 kB | Adobe PDF | Visualizar/Abrir |
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