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Title: Trypanosoma cruzi : induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.
Authors: Santos, Fabiane Matos dos
Caldas, Sérgio
Cáu, Stêfany Bruno de Assis
Crepalde, Geovam Pereira
Lana, Marta de
Coelho, George Luiz Lins Machado
Veloso, Vanja Maria
Bahia, Maria Terezinha
Keywords: Trypanosoma cruzi
Drug resistance
Treatment cycle
Issue Date: 2008
Citation: SANTOS, F. M. et al. Trypanosoma cruzi : induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection. Experimental Parasitology, v. 120, p. 385-390, 2008. Disponível em: <>. Acesso em: 20 ago. 2014.
Abstract: Through a continuous in vivo drug pressure protocol, using mice as experimental model, we induced benznidazole resistance in Trypanosoma cruzi stocks. Full resistance was obtained for four out of five T. cruzi stocks analyzed. However, the number of benznidazole doses (40–180), as well as the time (4–18 months) necessary to induce resistance varied among the different T. cruzi stocks. The resistance phenotype remained stable after T. cruzi stocks has been maintained by 12 passages in mice (six months) and in acellular culture for the same time. However, the maintenance of resistant parasite for 12 months in acellular culture induces a reduction in its level of benznidazole resistance, while no alteration was detected in parasite maintained for the same time in mice. The data showed the stability of the resistance acquired by drug pressure, but suggest the possibility of reversible changes in the resistance levels after maintenance for long time in acellular culture.
ISSN: 0014-4894
metadata.dc.rights.license: O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460321119735.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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