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Title: Trypanosoma cruzi : acute and long-term infection in the vertebrate host can modify the response to benznidazole.
Authors: Caldas, Sérgio
Santos, Fabiane Matos dos
Lana, Marta de
Diniz, Lívia de Figueiredo
Coelho, George Luiz Lins Machado
Veloso, Vanja Maria
Bahia, Maria Terezinha
Keywords: Trypanosoma cruzi
Chagas disease
Drug resistance
Cure control
Issue Date: 2008
Citation: CALDAS, S. et al. Trypanosoma cruzi : acute and long-term infection in the vertebrate host can modify the response to benznidazole. Experimental Parasitology, v. 118, p. 315-323, 2008. Disponível em: <>. Acesso em: 20 ago. 2014.
Abstract: We analyzed the influence of Trypanosoma cruzi maintenance in different hosts (dog and mouse) on its susceptibility to benznidazole treatment. Five T. cruzi stocks were isolated from dogs inoculated with Be-62 or Be-78 strain (both sensitive to benznidazole) 2–10 years ago, and the benznidazole sensitivity was then determined using the mouse as experimental model. The different T. cruzi stocks obtained from long-term infected dogs showed 50–90% drug resistance right after isolation. However, maintenance of these T. cruzi stocks in mice, by successive blood passages (2.5 years), led to either a decrease or stability of the drug resistance pattern and an increase in parasite virulence. We also demonstrated the effectiveness of the induction of parasitemia reactivation by cyclophosphamide immunosuppression in the evaluation of the response to the specific drug treatment.
ISSN: 0014-4894
metadata.dc.rights.license: O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3483170557595.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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