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http://www.repositorio.ufop.br/jspui/handle/123456789/3639
Title: | Simvastatin assay and dissolution studies by feasible rp-hplc in tablets. |
Authors: | Marinho, Flávia Dias Marques Santos, Amanda Leão dos Soares, Cristina Duarte Vianna Reis, Ilka Afonso Zanon, José Carlos da Costa Lima, Angélica Alves |
Keywords: | Simvastatin tablets Dissolution studies |
Issue Date: | 2012 |
Citation: | MARINHO, F. D. M. et al. Simvastatin assay and dissolution studies by feasible rp-hplc in tablets. Química Nova, v. 35, p. 1233-1238, 2012. Disponível em: <http://www.scielo.br/scielo.php?pid=S0100-40422012000600031&script=sci_arttext>. Acesso em: 20 ago. 2014. |
Abstract: | Commonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control assay and dissolution studies of this lipid-lowering drug were performed in diluents methanol and 0.01 M phosphate buffer with 0.5% SDS, pH 7, respectively. Dissolution test aliquots did not go through sample treatment, as described in USP SIM tablets monograph by ultraviolet spectrophotometry. The proposed method is fast, simple, feasible and robust. |
URI: | http://www.repositorio.ufop.br/handle/123456789/3639 |
metadata.dc.identifier.doi: | http://dx.doi.org/10.1590/S0100-40422012000600031 |
ISSN: | 1678-7064 |
metadata.dc.rights.license: | A Sociedade Brasileira de Química dá permissão à UFOP para reproduzir no RI/UFOP, uma cópia em formato eletrônico dos artigos completos, sem nenhuma edição e/ou modificação, publicados na revista Química Nova, que tenham como autores seus alunos e/ou professores. 17 set. 2013. |
Appears in Collections: | DEFAR - Artigos publicados em periódicos |
Files in This Item:
File | Description | Size | Format | |
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ARTIGO_SimvastatinAssayDissolution.pdf | 496,26 kB | Adobe PDF | View/Open |
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