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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Reis, Adriana Cotta Cardoso | - |
dc.contributor.author | Silva, Breno de Mello | - |
dc.contributor.author | Souza Filho, José Dias de | - |
dc.contributor.author | Pereira, Guilherme Rocha | - |
dc.contributor.author | Brandão, Geraldo Célio | - |
dc.date.accessioned | 2023-10-10T20:52:16Z | - |
dc.date.available | 2023-10-10T20:52:16Z | - |
dc.date.issued | 2022 | pt_BR |
dc.identifier.citation | REIS, A. C. C. et al. Cytotoxic activity of extracts from Tecoma species and isolated lignans. Brazilian Journal of Pharmaceutical Sciences, v. 58, artigo e181096, 2022. Disponível em: <https://www.scielo.br/j/bjps/a/BxyzcKRW6vkPSZbXm6xN4Bj/>. Acesso em: 01 ago. 2023. | pt_BR |
dc.identifier.issn | 2175-9790 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/17550 | - |
dc.description.abstract | A phytochemical study of Tecoma genus (Bignoniaceae) was accomplished by antitumor activity of ethanolic extracts. Species of this genus are composed of small shrubs often used as ornamental plants. The Tecoma stans species is used in folk medicine for different purposes. Recent work shows in vitro anticancer activity against human breast cancer. The ethanolic extracts from leaves and trunks of Tecoma casneifolia, T. garrocha, T. stans var. angustata and T. stans var. stans were tested in vitro. The assays used were against line tumor cells by the MTT method and the most active extracts were further studied. In this way, the ethanolic extract from T. stans var. stans trunks presented the higher cytotoxicity against the tumor cell lines studied (CC50 0.02 to 0.55 μg/ml) when compared to the other extracts tested (CC50 0.08 to 200.0 μg/ml). Accordingly, this extract was selected for chromatographic fractionation from which five known lignans were isolated. Further, paulownin, paulownin acetate, sesamin, olivil and cycloolivil were identified using 13C and 1 H NMR, IR, UV and spectroscopy and spectrometric MS techniques. These isolated compounds were tested and exhibited CC50 ranging from 13.01 to100.0 μg/ml which is superior to the ethanolic extract of trunk of T. stans. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | aberto | pt_BR |
dc.subject | Tecoma castaneifolia | pt_BR |
dc.subject | Tecoma garrocha | pt_BR |
dc.subject | Tecoma stans | pt_BR |
dc.title | Cytotoxic activity of extracts from Tecoma species and isolated lignans. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.rights.license | This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: PDF do artigo. | pt_BR |
dc.identifier.doi | https://doi.org/10.1590/s2175-97902022e181096 | pt_BR |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
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ARTIGO_CytotoxixActivityExtracts.pdf | 627,72 kB | Adobe PDF | Visualizar/Abrir |
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