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Title: Sodium butyrate-loaded nanoparticles coated with chitosan for the treatment of neovascularization in age-related macular degeneration : ocular biocompatibility and antiangiogenic activity.
Authors: Reis, Júlia Stephania dos
Teixeira, Aniely dos Reis
Quaresma, Amanda de Vasconcelos
Almeida, Tamires Cunha
Arribada, Raquel Gregorio
Neto, Julia Teixeira
Silva, Fábio Henrique Rodrigues da
Cunha Júnior, Armando da Silva
Moura, Sandra Aparecida Lima de
Silva, Glenda Nicioli da
Fialho, Sílvia Ligório
Silva, Gisele Rodrigues da
Keywords: Double emulsion
Double emulsification and solvent evaporation technique
Sodium butyrate
Sodium butyrate-loaded nanoparticles
Issue Date: 2022
Citation: REIS, J. S. dos et al. Sodium butyrate-loaded nanoparticles coated with chitosan for the treatment of neovascularization in age-related macular degeneration: ocular biocompatibility and antiangiogenic activity. European Journal of Pharmaceutics and Biopharmaceutics, v.179, p. 26-36, out. 2022. Disponível em: <>. Acesso em: 15 mar. 2023.
Abstract: Sodium butyrate-loaded nanoparticles coated chitosan (NaBu-loaded nanoparticles/CS) were developed to treat the choroidal neovascularization in wet age-related macular degeneration (AMD). The nanoparticles were produced by double emulsification and solvent evaporation technique, optimized by experimental statistical design, characterized by analytical methods, investigated in terms of in vitro and in vivo ocular biocompatibility, and evaluated as an antiangiogenic system in vivo. The NaBu-loaded nanoparticles/CS were 311.1 ± 3.1 nm in diameter with a 0.208 ± 0.007 polydispersity index; had a +56.3 ± 2.6 mV zeta potential; showed a 92.3 % NaBu encapsulation efficiency; and sustained the drug release over 35 days. The NaBu-loaded nanoparticles/CS showed no toxicity to human retinal pigment epithelium cells (ARPE-19 cells); was not irritant to the chorioallantoic membrane (CAM); did not interfere in the integrity of the retinal layers of rat’s eyes, as detected by the Optical Coherence Tomography and histopathology; and inhibited the angiogenesis in CAM assay. The NaBu-loaded nanoparticles/CS could be a therapeutic alternative to limit the neovascularization in AMD.
ISSN: 0939-6411
Appears in Collections:DEAMB - Artigos publicados em periódicos

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