Pre- and post-conditioning of the heart : an overview of cardioprotective signaling pathways.
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Data
2020
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Resumo
Since the discovery of ischemic pre- and post-conditioning, more than 30 years ago, the
knowledge about the mechanisms and signaling pathways involved in these processes has significantly
increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article pro-
vides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the
heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved
in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements
in the field. The advancements made over the last decades cannot be ignored and with the exponential
growth in techniques and applications. The future of pre- and post-conditioning is promising.
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Palavras-chave
Heart, Cardioprotective drugs, Ischemic pre-conditioning, Ischemic post-conditioning, Pre-pharmacological conditioning
Citação
MIRANDA, D. C. de et al. Pre- and post-conditioning of the heart : an overview of cardioprotective signaling pathways. Current Vascular Pharmacology, v. 19, p. 499-524, 2020. Disponível em: <https://www.eurekaselect.com/article/111703>. Acesso em: 11 out. 2022.