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http://www.repositorio.ufop.br/jspui/handle/123456789/12239| Título: | Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro. |
| Autor(es): | Silva, Marlene Lourenço da Stehmann, João Renato Serafim, Mateus Sá Magalhães Vale, Valdicley Vieira Gontijo, Douglas da Costa Brandão, Geraldo Célio Kroon, Erna Geessien Oliveira, Alaíde Braga de |
| Palavras-chave: | Yellow fever virus Plumieride Spectroscopic analyses |
| Data do documento: | 2019 |
| Referência: | SILVA, M. L. et al. Himatanthus bracteatus stem extracts present antiflavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro. Natural Product Research, nov. 2019. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1690487>. Acesso em: 10 fev. 2020. |
| Resumo: | The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97). |
| URI: | http://www.repositorio.ufop.br/handle/123456789/12239 |
| Link para o artigo: | https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1690487 |
| DOI: | https://doi.org/10.1080/14786419.2019.1690487 |
| ISSN: | 1478-6427 |
| Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
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| ARTIGO_HimatanthusBracteatusStem.pdf Restricted Access | 1,09 MB | Adobe PDF | Visualizar/Abrir |
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