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Title: Increase of binucleated cells in the oral mucosa : a study on the use of psychotropics by students of a Brazilian institution.
Authors: Oliveira, Luiza Barbosa de
Parreiras, Joyce Aparecida Rezende
Sebastião, Elza Conceição de Oliveira
Silva, Glenda Nicioli da
Keywords: Chromosome aberrations
Drugs utilization
Issue Date: 2019
Citation: OLIVEIRA, L. B. et al. Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution. Revista da Associação Medica Brasileira, São, Paulo, v. 65, n. 6, p. 870-879, jul. 2019. Disponível em: <>. Acesso em: 10 fev. 2020.
Abstract: This study aimed to assess the prevalence of medical and nonmedical use of psychiatric medication among undergraduate students of health sciences from a public university in Brasil. Another objective was to determine the frequency of nuclear morphological abnormalities in the buccal mucosa of students using psychiatric drugs. A cross-sectional study based on a Web survey was carried out with 375 health sciences undergraduate students from schools of Pharmacy, Physical Education, Nutrition, and Medicine. Additionally, spontaneous genetic damages in exfoliated cells of the buccal mucosa of 41 individuals by counting micronucleus (MN) and binucleated (BN) cells frequencies were evaluated. The results showed 76 (20.3%) of students reported the use of psychotropic drugs after enrolling in university. The majority of these students were from Pharmacy and Medicine programs, females, aged between 18-25 years old, nonsmokers, alcohol addicts, and with a family history of mental illness. In addition, Medical students, individuals with high-income, who live alone and are in the last period of the program are more likely to use psychotropic drugs. Moreover, exposure to psychiatric medication was able to increase the number of binucleated cells. These results provide evidence that the use of psychoactive drugs is increased in the academic context and may be related to the failure of the cell cycle.
ISSN: 1806-9282
metadata.dc.rights.license: This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo.
Appears in Collections:DEACL - Artigos publicados em periódicos

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