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http://www.repositorio.ufop.br/jspui/handle/123456789/10998
Título: | High fat diet modulates inflammatory parameters in the heart and liver during acute Trypanosoma cruzi infection. |
Autor(es): | Figueiredo, Vivian Paulino Lopes Júnior, Evandro Saraiva Lopes, Laís Roquete Simões, Natalia Figuerôa Penitente, Arlete Rita Bearzoti, Eduardo Vieira, Paula Melo de Abreu Schulz, Richard Silva, André Talvani Pedrosa da |
Palavras-chave: | VL-10 strain Inflammation Cytokines Matrix metalloproteinases |
Data do documento: | 2018 |
Referência: | FIGUEIREDO, V. P. et al. High fat diet modulates inflammatory parameters in the heart and liver during acute Trypanosoma cruzi infection. International Immunopharmacology, v. 64, p. 192-200, nov. 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1567576918304715?via%3Dihub>. Acesso em: 25 fev. 2019. |
Resumo: | The high fat diet (HFD) can trigger metabolic and cardiovascular diseases. Trypanosoma cruzi infection induces progressive inflammatory manifestations capable to affect the structure and the function of important organs such as the heart and liver. Here we aimed to investigate the effects of a HFD on the immune response and matrix metalloproteinase (MMP) activities during acute infection with the T. cruzi strain VL-10. The VL-10 strain has cardiac tropism and causes myocarditis in mice. Male C57BL/6 mice were treated with either: (i) regular diet (Reg) or (ii) HFD for 8 weeks, after which mice in each group were infected with T. cruzi. Mice were euthanized on day 30 after infection, and the liver and heart were subjected to histology and zymography to determine MMP-2 activities and plasma levels of IL-10, TNF, CCL2, and CCL5. T. cruzi-infected HFD animals had higher parasitemia, LDL and total cholesterol levels. Regardless of diet, plasma levels of all inflammatory mediators and cardiac MMP-2 activity were elevated in infected mice in contrast with the low plasma levels of leptin. HFD animals presented micro- and macrovesicular hepatic steatosis, while cardiac leukocyte infiltration was mainly detected in T. cruzi-infected mice. Our findings suggested that a HFD promotes higher circulating T. cruzi load and cardiac and liver immunopathogenesis in an experimental model using the VL-10 strain of the T. cruzi. |
URI: | http://www.repositorio.ufop.br/handle/123456789/10998 |
Link para o artigo: | https://www.sciencedirect.com/science/article/pii/S1567576918304715 |
ISSN: | 15675769 |
Aparece nas coleções: | DECGP - Artigos publicados em periódicos |
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Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_HighFatDiet.pdf Restricted Access | 2,78 MB | Adobe PDF | Visualizar/Abrir |
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