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Título : | Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs. |
Autor : | Carneiro, Cláudia Martins Martins Filho, Olindo Assis Reis, Alexandre Barbosa Veloso, Vanja Maria Araújo, Flávio Marcos Gomes de Bahia, Maria Terezinha Lana, Marta de Coelho, George Luiz Lins Machado Gazzinelli, Giovanni Oliveira, Rodrigo Corrêa de Tafuri, Wagner Luiz |
Palabras clave : | Dog Blood (BT) and metacycling (MT) trypomastigotes Trypanosoma cruzi Flow cytometry |
Fecha de publicación : | 2007 |
Citación : | CARNEIRO, C. M. et al. Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs. Acta Tropica, v. 101, n. 2, p. 120-129, fev. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X07000046>. Acesso em: 10 jul. 2012. |
Resumen : | Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs A detailed follow-up investigation of the major parasitological, serological and phenotypic features in dogs experimentally infected with metacyclic (MT) and blood (BT) trypomastigotes of Trypanosoma cruzi strain Berenice-78, typifying vectorial and transfusional transmission of human Chagas disease, has been conducted. Although there were no changes with respect to the window of patent-parasitaemia, significant differences between MT- and BT-infected dogs in both the prepatent period (days 23 and 19, respectively) and the day of maximum parasitaemia (days 26 and 22, respectively) were recorded. A progressive enhancement in the level of T. cruzi -specific antibodies accompanied infection by both MT and BT forms, although higher IgG titres developed on days 14 and 21 following infection with MT forms. Higher Thy-1 + /CD21 + and lower CD4 + /CD8 + cell ratios, occasioned by increased levels of Thy-1 + and CD8 + T-cells and reduced frequencies of CD4 + T-cells and CD21 + B-lymphocytes, were observed in both MT- and BT-infected animals. The reduced frequency of CD14 + leukocytes was revealed as the most relevant phenotypic feature intrinsic to T. cruzi infection independent of inoculum source. BT-specific phenotypic features included an early reduction |
URI : | http://www.repositorio.ufop.br/handle/123456789/1036 |
ISSN : | 0001706X |
metadata.dc.rights.license: | O periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990354506. |
Aparece en las colecciones: | DEACL - Artigos publicados em periódicos |
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